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Unformatted text preview: Template completed by: Metoprolol Lopressor® | Toprol XL® CLASS • Autonomic agent o Beta-blocker • Cardiovascular o Beta-blocker o Class II antiarrhythmics DESCRIPTION (basic summary) • Metoprolol is a competitive, beta-1 selective (cardioselective) adrenergic antagonist, which is most similar to atenolol MECHANISM OF ACTION • Like other beta-adrenergic antagonists, metoprolol competes with adrenergic neurotransmitters (e.g., catecholamines) for binding at sympathetic receptor sites. Similar to betaxolol and atenolol, metoprolol, in low doses, selectively blocks beta1-adrenergic receptors in the heart and vascular smooth muscle PHARMOKINETICS • Metabolism of metoprolol occurs primarily in the liver, which is characterized by extensive first-pass metabolism. Metoprolol is primarily metabolized by cytochrome P450 2D6. The rate of metabolism is dependent partly on the genetic polymorph that determines the rate of hepatic hydroxylation. In most subjects, hydroxylation occurs relatively rapidly, and the half-life of...
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.
- Fall '10