Metroprolol - Template completed by Metoprolol Lopressor |...

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Template completed by: Metoprolol Lopressor® | Toprol XL® CLASS Autonomic agent o Beta-blocker Cardiovascular o Beta-blocker o Class II antiarrhythmics DESCRIPTION (basic summary) Metoprolol is a competitive, beta-1 selective (cardioselective) adrenergic antagonist, which is most similar to atenolol MECHANISM OF ACTION Like other beta-adrenergic antagonists, metoprolol competes with adrenergic neurotransmitters (e.g., catecholamines) for binding at sympathetic receptor sites. Similar to betaxolol and atenolol, metoprolol, in low doses, selectively blocks beta1-adrenergic receptors in the heart and vascular smooth muscle PHARMOKINETICS Metabolism of metoprolol occurs primarily in the liver, which is characterized by extensive first-pass metabolism. Metoprolol is primarily metabolized by cytochrome P450 2D6. The rate of metabolism is dependent partly on the genetic polymorph that determines the rate of hepatic hydroxylation. In most subjects,
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