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Platelet Plug - matrix constituents that come in contact...

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Learning Issue: Pathophysiology of platelets-MH Platelet Plug Formation On vascular injury, platelets adhere to the site of injury, usually the denuded vascular intimal surface. Platelet adhesion is mediated primarily by von Willebrand factor (vWF). Platelet adhesion is also facilitated by direct binding to subendothelial collagen through specific platelet membrane collagen receptors. The adhesion results in subsequent platelet activation and aggregation. This process is enhanced and amplified by humoral mediators in plasma (e.g. epinephrine, thrombin); mediators released from activated platelets (e.g. adenosine diphosphate, serotonin); and vessel wall extra cellular
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Unformatted text preview: matrix constituents that come in contact with adherent platelets (e.g. collagen, vWF). Activated platelets undergo the release reaction, which they secrete contents that further promote aggregation and inhibit naturally anti-coagulant endothelial cell factors. During platelet aggregation (platelet-platelet interaction), additional platelets are recruited from the circulation of the site of vascular injury, leading to the formation of an occlusive thrombus. The platelet plug is anchored and stabilized by the developing fibrin mesh....
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