Hepatitis A - Learning Issue: Acute Hepatitis A-MH Dont...

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Learning Issue: Acute Hepatitis A-MH · Don’t Miss This: This is a huge topic, did my best to narrow it down. All of it seems important so I did not highlight anything. · Definition: Is a non-enveloped 27-nm, hear-, acid- and ether resistant RNA virus in the hepatovirous genus of the picornavirus family. Its viron contains four capsid polypeptides, designated VP1 to VP4, which are cleaved posttranslationally from the polyprotein product of 7500-nucleotide genome. · Etiology: Hepatitis A virus (HAV) has an incubation period of approximately 4 weeks. The viruses replications is limited to the liver, however is present in the liver, bile, stools, and blood during late incubation period and acute pre-icteric phase of illness. Infectivity diminishes rapidly once jaundice becomes apparent. Antibodies can be detected during acute illness when serum aminotransferase activity is elevated and fecal HAV shedding is still occurring. The early antibody response is of the IgM class and persists for several months. During convalescence anti- HAV of the IgG class becomes the predominant antibody. Thus IgM is diagnostic for acute
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Hepatitis A - Learning Issue: Acute Hepatitis A-MH Dont...

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