Metabolicacidosis.doc - Learning Issue: Metabolic Acidosis...

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Learning Issue: Metabolic Acidosis Name: Lindsay Francis *** This one is a summary. Metabolic acidosis is divided into several different categories, and each one is a learning issue in itself Definition clinical disturbance characterized by an increase in plasma acidity Sign of underlying disease process Metabolic acidosis is divided into a variety of types of metabolic acidoses  including:  Includes: lactic acidosis, ketoacidosis (alcoholic and diabetic),  drug and toxin  induced acidosis,  (alcohol, methanol, ethylene glycol, methanol, osopropyl  alcohol) , salicylate induced acidosis Causes 3 Main Mechanisms: 1. Increased Acid prodxn 2. Decreased Renal Acid secretion 3. Alkali loss Dehydration caused by Prolonged diarrhea is the most common cause of normal gap  metabolic acidosis Risk Factors Pathophysiology Acid-base homeostasis:  Systemic arterial pH is mainatianed between 7.35 and 7.45 by extracellular and  intracellular chemical buffering  This buffering generally involves respiratory and renal regulatory mechanisms:  Arterial CO 2 respiratory system---  plasma bicarbonate levels are controlled by kidneys.  These mechanisms combine to control blood pH via excretion  or retention of acid (through CO 2  ) or alkali (HCO 3 ).  Respiratory component:    Usually, CO 2  prodxn and excretion are matched  making a stable partial pressure of CO 2 Derrangements of the CO 2  partial pressure represent hypoventilation or  overproduction of CO 2  (usually the former)
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Metabolicacidosis.doc - Learning Issue: Metabolic Acidosis...

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