Learning issue: Polyps-MH Polyps are discrete mass lesions that protrude into the intestinal lumen. Although most commonly sporadic, they may be inherited as part of a familial polyposis syndrome. Polyps may be divided into three major pathologic groups: mucosal neoplastic (adenomatous) polyps, Mucosal nonneoplastic (hyperplastic, juvenile polyps, hamartomas, and inflammatory polyps), and submucosal lesions (lipomas, lymphoid, aggregates, carcinoids, pneumatosis cystoids inestinalis). The nonneoplastic mucosal polyps have no malignant potential and usually are discovered incidentally on colonoscopy or barium enema. Only the adenomatous polyps have significant clinical implications. Of polyps removed at colonoscopy, over 70% are adenomatous; most of the remainder are hyperplastic. Small hyperplastic polyps <5 mm located in the rectosigmoid region are of no consequence, except that they cannot reliably be distinguished from adenomatous lesions other than by biopsy. A large hyperplastic polyp located in the proximal
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