Sessile polyps - Learning Issue: Sessile serrated polyp...

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Learning Issue: Sessile serrated polyp (Colon Serrated Adenomas)-MH · Definition: Serrated polyps of the large intestine consist of those that display a lumen with a serrated or stellate architecture. Until recently, serrated polyps were though to consist only of benign and innocuous hyperplastic polyps. Recent discoveries have unveiled that, in addition to hyperplastic polyps, there exist other serrated lesions, for which natural history is not benign. · Clinical Features and Synonyms: In contrast to the left side “hyperplastic” polyps, right sided “serrated polyps are often >.5 cm, are sessile (attached directly by a broad base: not pedunculated), and contain significant architectural proliferative, and maturation abnormalities. Crypt distortion and abnormalities in proliferative characteristics, such as asymmetry in the proliferation and lack a readily identifiable proliferative zone, are hallmarks of these lesions. · Etiology: Etiology is unknown, recent research has shown an association with genetic alterations. · Risk Factors or Predisposing Factors: Close relative with Hx of colorectal cancer. · Epidemiology:
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Sessile polyps - Learning Issue: Sessile serrated polyp...

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