Trimethobenzamide or Tigan

Trimethobenzamide or Tigan - CONTRAINDICATIONS Absolute...

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Learning Issue: Trimethobenzamide-MH Barogan™ | Navogan™ | Tebamide® | Tigan® | Trimazide® | Trimethobenzamide CLASS Antiemetics NOTE: The FDA has concluded that suppositories containing trimethobenzamide have not been proven to be effective in the treatment of nausea and vomiting in adults and children. Patients currently on this therapy are urged to contact their health care professionals for further information and to request alternative treatment. DESCRIPTION (basic summary) It is an oral, rectal, and parenteral antiemeti agent, which is used to control nausea and vomiting. MECHANISM OF ACTION It is unknown, but may be mediated through the chemoreceptor trigger zone PHARMOKINETICS Administered PO, IM, or rectally. The exact route of metabolism in humans has not been clearly established 30-50% of a single dose is excreted in urine as unchanged drug within 48-72 hours following administration; 20% of an administered dose is excreted within 24 hours.
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Unformatted text preview: CONTRAINDICATIONS Absolute contraindications • children • ester local anesthetic hypersensitivity • infants • neonatal prematurity • neonates ADVERSE EFFECTS • Children with viral infection have increased risk of Reye’s syndrome • Severe vomiting;lethargy, irrational behavior, progressive encephalopathy leading to coma, seizures • Drowsiness is the most common side effect • Blurred vision, diarrhea, dizziness, headache, and muscle cramps are less frequent • Hypersensitivity such as skin rash, has been reported • Hypotension has been reported • Blood dyscrasias and jaundice have been reported INDICATIONS • Nausea and vomiting DOSAGE • Adults, 200 mg PO 3-4 per d as needed Notes • Do not use this medication, there are better options 1. Sources: Gold Standard Inc., and Elsevier Company; 2010. Iron Salts. . Accessed February 2 , 2011....
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Trimethobenzamide or Tigan - CONTRAINDICATIONS Absolute...

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