Carbamazepine monitoring - LFTs Absolute contraindications...

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Learning Issue: Carbamazepine Monitoring-MH Carbatrol® | Epitol® | Equetro® | Tegretol® | Tegretol® XR | Tegretol®- XR | Tegretol®-XR Monitoring parameters CBC LFTs Serum carbamazepine concentrations Serum cholesterol profile Urinalysis Monitor carbamazepine serum levels as indicated to evaluate therapeutic response, compliance, and possible toxicity. Assess CBC and renal and hepatic function prior to initiating therapy. Monitor renal and hepatic function periodically during treatment. Monitor CBC closely if, in the course of treatment, low or decreased WBC or platelet count is noted. Obtain baseline and periodic eye examinations, including slit-lamp, funduscopy, and tonometry. Obtain high- resolution HLA-B 1502 typing for patients who are genetically at risk. This paragraph is not from a credible resource, but wanted to highlight for about why to do a CBC, UA, and
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Unformatted text preview: LFTs. Absolute contraindications • Bone marrow suppression • Carbamazepine hypersensitivity • MAOI therapy • Porphyria • Tricyclic antidepressant hypersensitivity The adverse reactions that may occur with carbamazepine are fairly well described. The most severe adverse reactions have been observed in the hematologic system, the skin, liver, and the cardiovascular system. If adverse reactions are of such severity that carbamazepine must be discontinued, the practitioner must be aware that abrupt discontinuation of any anticonvulsant drug in a responsive epileptic patient may lead to drug withdrawal seizures or even status epilepticus, which may be life-threatening. Resource: • http://www.mdconsult.com/das/pharm/body/237529906-4/0/full/90 Cannot use this resource: http://www.drugs.com/ppa/carbamazepine.html...
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