Metabolic Syndrome

Metabolic Syndrome - Learning Issue: Metabolic Syndrome-MH...

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Learning Issue: Metabolic Syndrome-MH (Oops…I think I made long one) Definition: The major characteristics of metabolic syndrome include insulin resistance, abdominal obesity, elevated blood pressure, and lipid abnormalities. The WHO created an operation definition of metabolic syndrome as: the occurrence of any three of these abnormalities. Etiology: The etiology has not been established. o One hypothesis presumes that the primary cause is insulin resistance. The link between insulin resistance and cardiovascular disease probably is mediated by oxidative stress, which produces endothelial cell dysfunction, promoting vascular damage and atheroma formation. o The second hypothesis blames hormonal changes for the development of obesity. One study demonstrated that persons with elevated levels of serum cortisol (caused by chronic stress) developed abdominal obesity, insulin resistance, and lipid abnormalities. Risk Factors or Predisposing Factors: o Abdominal obesity o Atherogenic dyslipidemia o Raised blood pressure o Insulin resistance/glucose intolerance o Prothrombotic state
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Metabolic Syndrome - Learning Issue: Metabolic Syndrome-MH...

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