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Unformatted text preview: Learning Issue: Multiple Sclerosis-MH · Don’t Miss This: As MS lesions form axonal damage occurs, as axonal loss adds up, it is the main contributor to progressive and irreversible neurologic disability. Up to 70% of axons are lost from the lateral corticospinal tract in advanced MS. · Definition: Multiple sclerosis is defined by inflammation, demyelination, and gliosis (scarring). · Etiology: The cause is unknown. Inflammation occurs with mononuclear cells, majority of which are T cells and macrophages that infiltrate the white matter. When a lesion presents, it is often myelin specific antibodies are present, which promote demyelination while stimulating macrophages and microglial cells (bone marrow CNS phagocytes) . These cells scavenge myelin debris. Gliosis (scarring) occurs as a result of evolved lesions. · Risk Factors or Predisposing Factors: Vitamin D deficiency. High socioeconomic status and lack of exposure to infections are risk factors. There has been some linkage as a result of genes, with Caucasians at higher risk. The major contributor is MHC on chromosome 6. · Epidemiology: Women are threefold more common than men to develop MS. Onset is usually between 20-40 years old....
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.
- Fall '10