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Pick's Disease - characterized for personality and behavior...

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Learning Issue : Pick’s Disease-MH Definition: It is characterized by a preponderance of atrophy in the frontotemporal regions. Cause: The cause of Pick’s disease is unknown. Epidemiology: It accounts for 5% of all irreversible dementias. It is most common in men, especially those with a first degree relative with disease. One half of cases are familial. Pathogenesis: These regions also have neuronal loss, gliosis, and neuronal Pick’s bodies, which are masses of skeletal elements. Clinical findings: It is difficult to distinguish from Alzheimer’s, however early stages of Pick’s are more often
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Unformatted text preview: characterized for personality and behavior changes, with relative preservation of other cognitive functions, and typically begins before the age of 75. Familial cases may have an early onset. Kiluver-Bucy syndrome ( hypersexuality, placidity, and hyperorality) are more common in Picks’s than Alzheimer’s. Resource: Sadock BJ, Sadock AV. Synopsis of Psychiatry . 10 th ed. Philidelphia, PA: Lippincott Williams & Wilkins; 2007: 333....
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