TouretteSyndrome.docx - Tourette Syndrome Tshona Corbin...

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Tourette Syndrome Tshona Corbin What it is: A childhood neuropsychiatric disorder of motor and vocal tics. It has an association with OCD and ADHD, which may also be present in the patients. The condition does have a genetic component, but the specific genes have not yet been found. Pathophysiology: It is an inherited developmental disorder of synaptic neurotransmission, probably autosomal dominant. However, the actual mechanisms are unknown. The basal ganglia, especially the caudate nucleus and inferior prefrontal cortex are considered the most associated brain regions. The current explanation involves the disinhibition of the cortico-striatal- thalamic-cortical loops, leading to an overly active caudate nucleus. (This has also been seen in OCD and ADHD, so the association supports this). There is also a theory that increased D2 dopamine receptors leads to a supersensitivity to dopamine in the striatum, prefrontal cortex, and motor region. Frequency:
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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TouretteSyndrome.docx - Tourette Syndrome Tshona Corbin...

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