CollagenVascularDxTestsKA - Collagen Vascular Disease...

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Collagen Vascular Disease Definition Presentation Diagnostic Tests and Expected Result Other SLE RA Sjogrens Chronic autoimmune disease characterized by the sicca complex (dry eyes, dry mouth and lymphocytic infiltration of the exocrine glands) -Insidious -Dry eyes -Dry mouth -Fatigue -Arthralgias -Myalgias -Dry skin -Vaginal dryness -Schirmer test: test strip placed near lower conjunctiva to measure tear formation; normal persons wet 15mm or more after 5 minutes, a positive test is when less than 5 mm is wet after 5 minues -ESR: elevated -Rheumatoid factor: present in 52% of primary cases and 98% of secodnary cases -CBC: mild normochromic normocytic anemia present in 50%, leukopenia present in 42% - Anti SSA and Anti SSb: present -Creatinine clearance: diminished in 50% of patients Scleroderma (Systemic Sclerosis) -connective tissue disorder characterized -Raynaud’s phenomenon: inital -anti-ANA:homogenous, speckled, or nucleolar -female:male ratio 4:1
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by thickening and fibrosis of the skin and involvement of
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CollagenVascularDxTestsKA - Collagen Vascular Disease...

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