Roseola - Roseola DEFINITION Roseola is caused by the human...

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Roseola DEFINITION Roseola is caused by the human herpesvirus 6 (HHV-6) and is common in children There are 2 variants: HHV-6A and HHV-6B The typical presentation is that of roseola infantum or exanthem subitum, and seen in the 9-12 month-old Causes mononucleosis symptoms Graft recipients may also be affected ETIOLOGY May be transferred via saliva, genital secretions or in utero PATHOPHYSIOLOGY In primary infections, viral replication occurs in salivary glands and in the leukocytes Early invasion of CNS is believed to occur HHV-6 down-regulates host immune response by producing functional chemokine and chemokine receptors HHV-6 has been implicated in Kaposi sarcoma (caused by HHV-8) HHV-6 may facilitate oncogenic potential in lymphoma Associated with chronic fatigue syndrome HHV-6 may be associated with MS but has not been confirmed PRESENTATION Infants – High fever with or without rash; with or without seizures Notable in the presentation is lack of respiratory symptoms
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Roseola - Roseola DEFINITION Roseola is caused by the human...

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