Sunburns - Sunburns Definition Sunburn is an acute...

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Sunburns Definition Sunburn is an acute cutaneous inflammatory reaction that follows excessive exposure of the skin to ultraviolet radiation (UVR). UVR exposure can come from a variety of sources, including sun, tanning beds, phototherapy lamps, and arc lamps. Sunburn is generally classified as a superficial or first-degree burn. Pathophysiology Initially, UVR causes vasodilation of cutaneous blood vessels, resulting in the characteristic erythema. Within an hour of UVR exposure, mast cells release preformed mediators including histamine, serotonin, and tumor necrosis factor, leading to prostaglandin and leukotriene synthesis. Cytokine release additionally contributes to the inflammatory reaction, leading to an infiltrate of neutrophils and T lymphocytes. Within 2 hours after UV exposure, damage to epidermal skin cells is seen. Both epidermal keratinocytes ("sunburn cells") and Langerhans cells undergo apoptotic changes as a consequence of UVR- induced DNA damage.
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Sunburns - Sunburns Definition Sunburn is an acute...

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