AcneVulgaris - P acnes a G rod metabolizes and releases...

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Acne Vulgaris Definition: Acne vulgaris is a skin disease affecting the pilosebaceous unit. It is characterized by comedones, papules, pustules, nodules, cysts, and/or scarring, primarily on the face and trunk. Acne is most common in adolescents , but may occur at any age. In addition to the physical lesions, acne can have profound psychological and social impact on patients Epidemiology: Affects 40-50 million people annually in the US. 85% of people between 12-24 have acne 8% of adults 25-34 have acne 3% of adults 35-44 have acne Most common in boys in adolescence, but more common in females during adulthood More prominent in white people. Pathophysiology: Formation of a microcomedo Follicular keratinocytes which are increasingly cohesive do not shed normally, leading to retention and accumulation. Androgen stimulates sebaceous gland enlargement and increases sebum production The combined effect leads to the formation of a microcomedo Built up pressure causes a noninflammatory comedo and
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Unformatted text preview: P acnes , a G- rod, metabolizes and releases fatty acids ○ This causes a proinflammatory mediator response ● Microcomedos then may rupture releasing keratin and sebum. Risk factors: ● Genetic predisposition ● Greasy skin/increased sebum production ● Endocrine disorders ● Dietary factors ● Obesity/insulin resistance ● Corticosteroid use Presentation: ● Comedones (noninflammatory lesions) ● Papules, pustules, nodules, cysts (inflammatory lesions) ● Hyperpigmentation/scarring (postinflammatory) ● Skin tenderness ● Depression, social isolation Diagnostics: ● Presentation ● Hormone evaluation ● Bacterial culture Treatment: ● Mild-moderate: Tretinoin topical AND benzoyl peroxide topical ● Severe: Oral Retinoid AND oral corticosteroids https :// online . epocrates . com / noFrame / showPage . do ? method = diseases & MonographId =101& ActiveSectionId =11...
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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