Unformatted text preview: P acnes , a G- rod, metabolizes and releases fatty acids ○ This causes a proinflammatory mediator response ● Microcomedos then may rupture releasing keratin and sebum. Risk factors: ● Genetic predisposition ● Greasy skin/increased sebum production ● Endocrine disorders ● Dietary factors ● Obesity/insulin resistance ● Corticosteroid use Presentation: ● Comedones (noninflammatory lesions) ● Papules, pustules, nodules, cysts (inflammatory lesions) ● Hyperpigmentation/scarring (postinflammatory) ● Skin tenderness ● Depression, social isolation Diagnostics: ● Presentation ● Hormone evaluation ● Bacterial culture Treatment: ● Mild-moderate: Tretinoin topical AND benzoyl peroxide topical ● Severe: Oral Retinoid AND oral corticosteroids https :// online . epocrates . com / noFrame / showPage . do ? method = diseases & MonographId =101& ActiveSectionId =11...
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- Fall '10
- Fatty Acids, social isolation, Sebaceous gland, benzoyl peroxide, tretinoin