Definition: Psoriasis is a chronic, noncontagious, multisystem, inflammatory disorder, which most
commonly manifests itself on the skin of the elbows, knees, scalp, lumbosacral areas, intergluteal clefts,
and glans penis.
etiology of flareups:
infections (eg, streptococcal, staphylococcal, human immunodeficiency virus)
alcohol, and drugs (eg, iodides, steroid withdrawal, aspirin, lithium, beta-blockers,
botulinum A, antimalarials))
about 2.2% of the population
slightly more women than men
more in lighter skinned people
most common type: plaque-type psoriasis, also known as discoid psoriasis
epidermis is infiltrated by a large number of activated T cells, which appear to be capable of
inducing keratinocyte proliferation.
other cytokines follow, causing an inflammation
one major cytokine, TNF alpha, increase in number and have been associated with flareups