psoriasis - LI Psoriasis Definition Psoriasis is a chronic...

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LI: Psoriasis Definition: Psoriasis is a chronic, noncontagious, multisystem, inflammatory disorder, which most commonly manifests itself on the skin of the elbows, knees, scalp, lumbosacral areas, intergluteal clefts, and glans penis. Risk factors: family history obesity etiology of flareups: cold trauma infections (eg, streptococcal, staphylococcal, human immunodeficiency virus) alcohol, and drugs (eg, iodides, steroid withdrawal, aspirin, lithium, beta-blockers, botulinum A, antimalarials)) epidemiology about 2.2% of the population slightly more women than men more in lighter skinned people most common type: plaque-type psoriasis, also known as discoid psoriasis pathophysiology: 1. epidermis is infiltrated by a large number of activated T cells, which appear to be capable of inducing keratinocyte proliferation. 2. other cytokines follow, causing an inflammation 3. one major cytokine, TNF alpha, increase in number and have been associated with flareups symtpoms
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