Atopicdermatitis - Learning Issue: Atopic Dermatitis Name:...

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Learning Issue: Atopic Dermatitis Name: Lindsay Francis Definition Pruritic disease characterized by pruritis, eczematous lesions, xerosis, and lichenificiation (skin thickening and increased skin markings) May be associated with asthma, allergic rhinitis, urtuicaria, acute allergic reaction, etc Usually starts in early infancy Typically relapsing-remitting Causes Genetically inherited Associated with loci 3q21, 1q21, 16q, 17q25, 20p, 3p26 Genes that are involved in IgE synthesis are also suspected Extremes of heat may instigate atopic dermatitis (hot or cold) Infection S. aureus may act as a super antigen, and body over reacts to it causing atopic dermatitis Hygeine Reduced childhood exposure to childhood infections and bacterial endotoxins leads to atopic dermatitis Food antigens: Food instigating atopic dermatitis is disputed; usually a food allergy accompanies atopic dermatitis Risk Factors Children: 10-12% prevalence (US) Adults: .9% prevalence (US) Male to female prevalence: 1: 1.4 Immigrants more likely to develop atopic dermatitis Pathophysiology Atopic dermatitis’s pathophysiology is not fully understood but there are 2 theories: Immune dysfunction
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Atopicdermatitis - Learning Issue: Atopic Dermatitis Name:...

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