GERD - Learning Issue: Gastroesophageal Reflux Disease...

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Learning Issue: Gastroesophageal Reflux Disease (GERD)-MH Definition: It is a normal physciologic phenomenon experienced intermittently by most people, particulary after a meal. It typically occiurs when the amount of gastric juice that refluxes into the esophagus exceeds the normal limit causing symptoms with or without associated esophageal mucosa injury. Etiology: Excessive retrograde movement of acid containing gastric secretions or bile and acid containing secretions from the duodenum and stomach into the espophagus is the etiologic effector of GERD. o Functional: Frequent transient LES relaxation can be caused by foods such as coffess, alcohol, chocolate, and fatty meals. Medications can contribute to transient LES relaxtion such as B-blockers, CCB, anticholinergics, progesterone, and nicotine. o Mechanical: Hypotensive LES Epidemiology: 25-45% of Americans experience symptomatic GERD at some point and 7-10% on a daily basis. The prevalence increases after age 40. Pathophysiology:
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GERD - Learning Issue: Gastroesophageal Reflux Disease...

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