Varicella (Chicken Pox)

Varicella (Chicken Pox) - Learning Issue: Varicella...

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Learning Issue: Varicella (Chicken Pox)-MH Definition: o Is the etiologic agent of the clinical syndrome chickenpox. It is a double stranded deoxyribonucleic acid virus included in the Alphaherpesvirinae subfamily. Etiology: o Is acquired by inhalation of airborne respiratory droplets from a VZV-infected host. Transmission can be spread through direct contact with open vesicles. Epidemiology: o Most commonly occurs in pediatric population o No racial or sexual predilection o Incidence has declined up to 90%, and mortality decreased by 66% due to US vaccination program Pathophysiology: o After initial inhalation of contaminated respiratory droplets, the virus infects the conjunctivae or the mucosa of the upper respiratory tract. o Viral proliferation occurs in regional lymph nodes of upper respiratory tract 2-4 days after initial infection; this is followed by primary viremia on post-infection days 4-6 days. o A second round of viral replication occurs in the bodies internal organs, most notably the liver and spleen, followed by secondary viremia 14-16 days post
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Varicella (Chicken Pox) - Learning Issue: Varicella...

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