Erythema infectiosum (fifth disease)

Erythema infectiosum (fifth disease) - Learning Issue:...

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Learning Issue: Erythema Infectiosum (Fifth Disease)-MH Definition: o Is a common childhood exanthema caused by human parvorius B-19 (PV-B19), and erythrovirus, in which a classic 3 phased cutaneous eruption follows a rarely noticed prodrome Etiology: o Caused by infection with PV-B19, a member of the Parvoviridae family. o PV-B19 is the virus with the smallest DNA known to cause illness in humans, and it consists of a single-stranded DNA core surrounded by an unenveloped icosahedral capsid Epidemiology: o Tends to occur in late winter or early spring, with cyclical peaks every 4-7 years o 60% of adults are seropositive for PV-B19 by age 20 years. o Infection rates vary from 20-50% in households o Self-limited o Males and females affected equally o Peak incidence are in children 3-15, but can occur at any age Pathophysiology: o In children it is a normal response to infection of the PV-B19 o Immunocompetent patients have a Th-1-mediated cellular immune response, with production of specific immunoglobulin M (IgM) antibodies and subsequent
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Erythema infectiosum (fifth disease) - Learning Issue:...

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