Angioedema - Learning Issue Angioedema-MH Again I apologize...

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Learning Issue: Angioedema-MH Again I apologize for the copy and paste, but did not have time to read through everything. If anyone needs me to further modify this please let me know. Definition: The general term angioedema is described as deep, subcutaneous, submucosal edema due to increase vascular permeability. It can manifest as an episodic or self-limiting event, but can often be described as recurrent. Acute episodes may involve the skin, larynx, and buccal and GI mucosa. Etiology: Angioedema can be categorized as allergic, pseudoallergic, nonallergic, or idiopathic. More than 40% of chronic angioedema is idiopathic. All cases of angioedema pose significant diagnostic and treatment challenges. Epidemiology: Eighty-five percent of patients who experience angioedema not associated with urticaria have type I HAE. Approximately 1 out of 10,000 patients have recurrent angioedema classified as type I. Type II HAE occurs in 1 out of 50,000 people. Angioedema induced by ACE inhibitors occurs at a frequency of 0.1-0.7%. Peak incidence in 4rd decade of life. Pathophysiology: Angioedmia without urticaria is hereditary angioedema (HAE) or acquired C1 inhibitory deficiency (AAE/ACID). Is a result of qualitative or quantitative
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Angioedema - Learning Issue Angioedema-MH Again I apologize...

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