Learning Issue: Metabolic acidosis physiology-MH • Causes: o Metabolic Acidosis is caused by an increase in HCO3 concentration that, according to Henderson-Hasselbach equation, leads to a decrease in pH. The disorder is caused by a gain of fixed H, ingestion of fixed H, or decreased excretion of fixed H. o Can result from increased production of fixed acids such as ketoacids or lactic acids; from ingestion of fixed acids such as salicyclic acid; inability of the kidneys to excrete the fixed acids produced from normal metabolism; or loss of bicarbonate via the kidneys or the GI tract. • Effects: o Decrease pH o Decrease HCO3 o Decrease PCO2 • Pathophysiology: o Gain of Fixed H Excess fixed H is accumulated in the body o Buffering The excess H is buffered in both ECF and ICF, the H is buffered primarily by HCO3, which produces a decrease in HCO3 concentration. Decrease in HCO3 causes a decrease in pH. In the ICF, the excess H is buffered by organic phosphates and proteins. To
This is the end of the preview.
access the rest of the document.