HepBChronicVSAcute.docx - ● HBsAG, HBcAb of IgG type and...

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Learning Issue: Hepatitis B; how does blood work indicate chronic vs acute Hep B Nicole Banfield 4/5/11 Laboratory Studies: Acute hepatitis B High levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) at a range of 1000-2000 IU/mL is the hallmark of the disease ALT levels are usually higher than AST levels Alkaline phosphatase (ALP) levels may be elevated, but usually no more than 3 times greater than the upper limit; normal range is between 5 IU/L to 60 IU/L Albumin levels may be slightly low and serum iron levels may be elevated HBsAg and HBeAg are the first markers identified in the serum, then HBcAb (IgM) Patients with persistent HBsAg for more than 6 months develop chronic hepatitis Chronic inactive hepatitis B Healthy carries have normal AST and ALT levels; markers of infectivity may be negative (HBeAg, HBV DNA)
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Unformatted text preview: ● HBsAG, HBcAb of IgG type and HBeAb are present in the serum Chronic active hepatitis B ● Mild to moderate elevation of ALT and AST ● ALT levels are usually higher than AST levels ● During periods of exacerbation or reactivation of the diseases extremely high levels of ALT can be observed along with high levels of HBV DNA levels ● HBsAg and HBcAb of IgG or IgM type are also found in the serum ● When the IgG globulins are elevated it results in hyperglobulinemia ● Tissue nonspecific antibodies, including antismooth muscle antibodies (ASMAs) or antinuclear antibodies (ANAs) can be identified ● Mildly elevated levels of rheumatoid factor are commonly present along with tissue-specific antibodies, such as antibodies against the thyroid gland References: http :// emedicine . medscape . com / article /177632-workup...
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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