Hodgkindisease04-04-11.docx - Hodgkin disease (Lymphoma) In...

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Hodgkin disease (Lymphoma) In classic Hodgkin disease (Hodgkin's lymphoma), the neoplastic cell is the Reed- Sternberg (RS) cell. Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils, and histiocytes . Most Reed-Sternberg cells are of B-cell origin, derived from lymph node germinal centers but no longer able to express antibodies. Epstein-Barr virus has been found in the Reed-Sternberg cells of about 50% of patients with Hodgkin disease and appears to have a crucial role in the development of Hodgkin disease Hodgkin disease (Hodgkin's lymphoma) exists in 5 types. Four of these, nodular sclerosis, mixed cellularity, lymphocyte depleted, and lymphocyte rich, are referred to as classic Hodgkin disease (Hodgkin's lymphoma). The fifth type, nodular lymphocyte predominant Hodgkin disease (NLPHD), is a distinct entity with unique clinical features and a different treatment paradigm. Epidemiology
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Hodgkindisease04-04-11.docx - Hodgkin disease (Lymphoma) In...

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