Lyme Disease

Lyme Disease - Learning Issue-Lyme Disease-MH Epidemiology...

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Learning Issue -Lyme Disease-MH Epidemiology Lyme disease is the fastest growing vector-borne disease in the United States, with infection occurring most often between May and November, with a peak incidence in June and July Although year-to-year variation is significant, approximately 20,000 cases are reported annually in the United States Most of the states in the United States have reported Lyme disease; however, more than 95% of cases come from 12 states (Connecticut, Delaware, Maine, Maryland, Massachusetts, Minnesota, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Wisconsin). Etiology Ixodes (deer ) ticks, which transmit B burgdorferi from host to host Pathophysiology Manifestations of disease are caused by a spirochete; others by immunologic mechanisms Although any part of the body can be affected, after entering the circulation, the organism shows a distinct tropism for the skin, heart, central nervous system (CNS), joints, and eyes. Spirochetes have also been demonstrated histologically in bone marrow, the spleen, lymph nodes, the liver, testes, and the placenta during early hematogenous dissemination Stages of Disease Stage 1 o Once B burgdorferi is injected into the host, patients may clear the infection without developing any manifestations, as demonstrated by patients who are asymptomatic but seropositive. Stage 2 o B burgdorferi spreads throughout the body and produces symptoms by direct invasion (eg, erythema migrans), particularly in the early stages of the disease Stage 3 o B burgdorferi induces an immune response that may lead to symptoms in various
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Lyme Disease - Learning Issue-Lyme Disease-MH Epidemiology...

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