Chem 161-2011 Lecture 11 2PLAN FOR TODAY•Molecular Geometry The VSEPR model Electron-domain geometry and molecular geometry Deviation from ideal bond angles Geometry of molecules with more than one central atom •Molecular Geometry and Polarity •Valence Bond Theory •Hybridization of Atomic Orbitals Hybridization of s and p orbitals Hybridization of s, p, and d oritals •Hybridization in molecules containing multiple bonds Bonding Theories and Descriptions of Molecules with Delocalized Bonding
Chem 161-2011 Lecture 11 3VSEPRValence Shell Electron Pair Repulsion•Electron pairs surrounding a central atom keep as far away from each other as possible in order to minimize electron repulsion. •Lewis structures provide two-dimensional geometry. •VSEPR provides three-dimensional geometry, including molecular polarity. Similar molecular shapes often govern chemical and biological activity. e.g., Sulfanilamide and para-aminobenzoic acid: both antibiotics e.g., Colgate-Palmolive research Triclosan2-Isopropoxyphenol: model compound for triclosan OHOClClClOHO
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Chem 161-2011 Lecture 11 4Heroin Naloxone The receptor sites in human body proteins have three-dimensional shapes designed to accommodate certain molecules produced naturally in the body. Some drug molecules, e.g., heroin, fit into these receptor sites due to its shape. However, naloxone, which has a similar shape as morphine, can also fit the receptor site and block the action of heroin.