Chem 161-2011 Lecture 11 truncated, Chapter 7

Chem 161-2011 Lecture 11 truncated, Chapter 7 - CHEMISTRY...

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Chem 161-2011 Lecture 11 1 CHEMISTRY 161-2011 LECTURE 11 CHAPTER 7 MOLECULAR GEOMETRY AND BONDING THEORIES ANNOUNCEMENTS E-MAIL EXAMS How did we do?
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Chem 161-2011 Lecture 11 2 PLAN FOR TODAY Molecular Geometry The VSEPR model Electron-domain geometry and molecular geometry Deviation from ideal bond angles Geometry of molecules with more than one central atom Molecular Geometry and Polarity Valence Bond Theory Hybridization of Atomic Orbitals Hybridization of s and p orbitals Hybridization of s, p, and d oritals Hybridization in molecules containing multiple bonds Bonding Theories and Descriptions of Molecules with Delocalized Bonding
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Chem 161-2011 Lecture 11 3 VSEPR Valence Shell Electron Pair Repulsion Electron pairs surrounding a central atom keep as far away from each other as possible in order to minimize electron repulsion. Lewis structures provide two-dimensional geometry. VSEPR provides three-dimensional geometry, including molecular polarity. Similar molecular shapes often govern chemical and biological activity. e.g., Sulfanilamide and para-aminobenzoic acid: both antibiotics e.g., Colgate-Palmolive research Triclosan 2-Isopropoxyphenol: model compound for triclosan OH O Cl Cl Cl OH O
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Chem 161-2011 Lecture 11 4 Heroin Naloxone The receptor sites in human body proteins have three-dimensional shapes designed to accommodate certain molecules produced naturally in the body. Some drug molecules, e.g., heroin, fit into these receptor sites due to its shape. However, naloxone, which has a similar shape as morphine, can also fit the receptor site and block the action of heroin.
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