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Unformatted text preview: Stats for Clinical Trials, Math 150 Jo Hardin Homework # 2, Due: Thurs, 9/18/10 1. Eisenhofer et al. (1999) investigated the use of plasma normetanephrine and metanephrine for detecting pheochromocytoma in patients with von Hippel-Lindau disease and mul- tiple endocrine neoplasia type 2. The data set (vonHippelLindau.csv) contains data from this study on 26 patients with von Hippel-Lindau disease and nine patients with multiple endocrineneoplasia. The variables in the data set are ( problem from Dupont, chp 2.22 ): disease = 0: patient has von Hippel-Lindau disease; 1: patient has multiple endocrine neoplasia type 2 p_ne = plasma norepinephrine (pg/ml) tumorvol = tumor volume (ml) Use R for the following problems. (a) Regress plasma norepinephrine against tumor volume. Draw a scatter plot of norepinephrine against tumor volume together with the estimated linear regres- sion curve. What is the slope estimate for this regression? What proportion of the total variation in norepinephrine levels is explained by the regression?the total variation in norepinephrine levels is explained by the regression?...
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