Chapter 6 Chem114A

Chapter 6 Chem114A - Bioinformatics(Chapter 6 Homology...

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Bioinformatics (Chapter 6) • Homology • Sequence Alignments • Structural Alignments • Evolutionary Trees • Combinatorial Chemistry Saturday, November 5, 2011
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Bioinformatics • Homology • Sequence Alignments • Structural Alignments • Evolutionary Trees • Combinatorial Chemistry Saturday, November 5, 2011
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Homologous = Same origin Paralogs: homologs that are in the same species. Function might differ. Originated by gene duplication. Orthologs: homologs that are in different species. Function tends to be the same. Originated by speciation. What is homology? Saturday, November 5, 2011
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Saturday, November 5, 2011
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Bioinformatics • Homology • Sequence Alignments • Structural Alignments • Evolutionary Trees • Combinatorial Chemistry Saturday, November 5, 2011
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Sequence Alignments • Sequence alignment methods can detect homologous genes or proteins . • To use protein sequences is more sensitive. Saturday, November 5, 2011
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A simple scoring matrix for DNA A C G T A 1 0 0 0 C 0 1 0 0 G 0 0 1 0 T 0 0 0 1 Saturday, November 5, 2011
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A more useful scoring matrix for A C G T A 2 -3 -3 -3 C -3 2 -3 -3 G -3 -3 2 -3 T -3 -3 -3 2 Saturday, November 5, 2011
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A not-so-simple scoring matrix Saturday, November 5, 2011
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Why are the matrices so different? Conservation:
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Chapter 6 Chem114A - Bioinformatics(Chapter 6 Homology...

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