0157h7 - The body's first line of defense for the bacteria...

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The body’s first line of defense for the bacteria E. coli 0157:H7 is the immune system. In order to fully understand why the bacteria are successful in manipulating the body, one must first address the processes that the body goes through when infected by the 0157:H7 pathogen. Upon ingestion of the bacteria, the pathogen makes its way down to the intestines and begins to adhere to the microvilli that cover the surface of the intestines. The bacteria then proceeds to its Type III Secretion System (TTSS or T3SS), this secretion system is a protein appendage that is consistent with gram negative bacteria. This structure that the bacterium is equipped with is needle-like and is used by 0157 to detect when there are any eukaryotic organisms so that the T3SS can secrete proteins that help the bacteria infect them. Once the T3SS is attached the receptors are sent into the eukaryotic cell directly. After all the receptors are launched into the cell the needle like T3SS retracts, allowing the bacteria to fasten to the actual cell membrane. The receptors inside the cell begin to attract monomers that start to build a special protein for the bacteria. The allocation of the bead like monomers created a large protein that pushes the bacteria up on top of the cell on a “thrown”. Once the bacteria have staked out the plot of the cell it wants, it then allows the shiga like toxin to do its job. This toxin acts on the blood vessels in the intestines, or the vascular endothelium. The toxin is made up of subunits that each has a particular function. The B subunit binds to the part of the cell known as the Gb3 and causes the induction of narrow tubular membrane invaginations (inward folds). These invaginations go on to drive the formation of
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inward membrane tubules for bacterial uptake. It is then the A subunit’s duty to inactivate the
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This note was uploaded on 02/21/2012 for the course AG 3314 taught by Professor Rahe during the Fall '11 term at Texas State.

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0157h7 - The body's first line of defense for the bacteria...

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