1.24.12 ch 1 - Psychology 503 Drug Use and Effects 1.24.12...

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Psychology 503 Drug Use and Effects 1.24.12
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Review 1.19.12
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1. Route of Administration 2. Is the drug lipid soluble?
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Various Barriers to Distribution and Absorption 1. Depot Binding 2. Blood Brain Barrier 3. Placental Barrier
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Metabolism and Excretion Biotransformation (metabolism) and elimination (excretion)… of drugs contributes to bioavailability.
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Rate of Excretion (Half Life) The top panel shows a typical excretion curve for a drug like nicotine, which has a half-life of about 30 minutes. The bottom panel shows the excretion function for alcohol, which is excreted at a constant rate ( about 15 mg/100 ml of blood per hour ). Because the excretion function for alcohol is a straight line, the concept of half-life does not apply. 1st order kinetics Zero-order kinetics
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Factors which affect the rate of metabolism 1. Enzyme induction 2. Enzyme inhibition 3. Genetic Variations (Polymorphisms)
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Liver biotransformation results in metabolites that are highly ionized. The
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This note was uploaded on 02/21/2012 for the course PYSC 503 taught by Professor Mr.harrod during the Spring '12 term at South Carolina.

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1.24.12 ch 1 - Psychology 503 Drug Use and Effects 1.24.12...

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