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1.19.12 ch 1 - Psychology 503 Drug Use and Effects 1.19.12...

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Psychology 503 Drug Use and Effects 1.19.12
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Review 1.17.12
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Drug Interactions
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Agonist Antagonist Nicotine Mecamylamine Acetylcholine (endogenous neurotransmitter)
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Drug Interactions Drug Antagonism and Dose Response Curve Antagonism moves the ED50 to the right… This is called “shifting” the dose-response curve. Example: Naloxone and heroin
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Drug Interactions Drug Antagonism Shifts the dose response to the right L = DR curve: no antagonist. L’= DR curve: 20 mg/kg antagonist. L’’= DR curve: 60 mg/kg antagonist. L’’= DR curve: 200 mg/kg antagonist.
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Example: Harrod Lab DRC DRC are used all the time in research. Established DRC for animals prenatally exposed to nicotine or to saline (control). Research Question : Does prenatal nicotine exposure alter the sensitivity to IV methamphetamine (METH) in adult offspring?
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IV METH DRC Controls
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IV METH DRC Controls Nicotine-exposed
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IV METH DRC
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Pharmacokinetic factors Chemical structure is not the only factor that determines a drug’s action: 1. Route of Administration 2. Absorption and Distribution 3. Binding 4. Biotransformation ( inactivation ) 5. Excretion
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Circulatory System The circulatory system. The heart circulates blood returning from the body via the veins and the lungs and then sends it out via arteries to the body and the brain.
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Route of Administration PARENTERAL ROUTES 2.
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