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1.12.12 ch 1 - 1/1000 of a gram • Doses given in...

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1.12.12 Psychology 503
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Announcements 1.12.12 Few more comments about class…
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What is a drug? How do we define a drug?
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What is a drug? How do we define a drug?
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Drug Names
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Example Drug 1 Structure Chemical Name 2,6-diisopropylphenol
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Example Drug 1 Generic or International Non-Proprietary Name (INN): Propofol Trade or Proprietary Name: Diprivan
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Example Drug 2 Structure Chemical Name (+)-( S )- N -Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-
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Example Drug 2 Generic Name : Duloxetine Proprietary Name : Cymbalta (Ariclaim , Xeristar , Yentreve , Duzela).
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Example Drug 3 Structure Chemical Name (+)-5-methyl-10,11- dihydro-5 H -dibenzo[ a , d ]cyclohepten-5,10-imine
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Example Drug 3 Generic Trade Name : Dizocilpine Commonly known by its letter/number code, MK-801. No Proprietary Name because it is an experimental drug . MK-801: Merk; 801st compound in a series of synthesis…
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Dosages Describing Doses Milligrams:
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Unformatted text preview: 1/1000 of a gram • Doses given in accordance to body weight • 1 mg/kg dose for human • 270 lbs = 122.7 kg • 122 mg dose Dose Response Curves Dosages and Dose Response Curves Describing Dosages • ED50 • The Median effective dose • The dose that is effective in 50% of the subjects tested. • LD50 • Median lethal dose • The dose that was lethal in 50% of the subjects tested. ED50 and LD50 Results of a hypothetical experiment using 12 groups. One curve shows the percentage of animals in each group that lost consciousness; the other curve shows the percentage that died at each dose. Potency and Effectiveness • The extent of the drugs effect • They do not mean the same thing. • Potency • Differences in the ED50 • Effectiveness • Differences in the maximum effect that drugs will produce at any dose. Potency and Effectiveness...
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