Smooth Muscle - Smooth Muscle Phosphorylation of a light...

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Smooth Muscle: Phosphorylation of a light chain leads to a conformational change of the head that allows it to bind to actin. (made possible through myosin light chain kinase, which is turned on by an increase in CA). To Control CA levels: IP3 Gated on sarcoplasmic reticulum: Releases Ca from the SER. Voltage Gated channel on Sarcolemma: Ca moves into the cell by voltage gated CA channel (Calveolae in smooth muscle-pockets in the sarcolemma- have invaginations where there are a lot of voltage gated CA channels, similar to the sarcoplasmic reticulum in skeletal muscle) The CA that is released binds to CALMODULIN. (similar to the TnC on the troponin in skeletal muscle). This creates a Ca/Calmodulin complex. The importance of this complex, is that the myosin light chain complex binds to the calcium/calmodulin complex. The binding of the myosin light chain complex to the calcium/calmodulin complex is that it activates MLCK and increases it’s kinase ability.
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