Smooth Muscle - Smooth Muscle: Phosphorylation of a light...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Smooth Muscle: Phosphorylation of a light chain leads to a conformational change of the head that allows it to bind to actin. (made possible through myosin light chain kinase, which is turned on by an increase in CA). To Control CA levels: IP3 Gated on sarcoplasmic reticulum: Releases Ca from the SER. Voltage Gated channel on Sarcolemma: Ca moves into the cell by voltage gated CA channel (Calveolae in smooth muscle-pockets in the sarcolemma- have invaginations where there are a lot of voltage gated CA channels, similar to the sarcoplasmic reticulum in skeletal muscle) The CA that is released binds to CALMODULIN. (similar to the TnC on the troponin in skeletal muscle). This creates a Ca/Calmodulin complex. The importance of this complex, is that the myosin light chain complex binds to the calcium/calmodulin complex. The binding of the myosin light chain complex to the calcium/calmodulin complex is that it activates MLCK and increases it’s kinase ability. These channels have a control over CA, and thus the activation of the
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 2

Smooth Muscle - Smooth Muscle: Phosphorylation of a light...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online