Hyaluronic Acid (HA) HA was initially discovered in a vitreous body of cattle eye and was later found to be distributed all throughout the body, especially in the extracellular matrix of cells and synovial fluids. It is usually produced through microbial fermentation instead of isolating it from living tissue because it reduces the risk of contamination and infection. Functions: • cell-cell/cell-substrate adhesion • cell migration • proliferation • aid in organization of proteoglycans • bind collagen and fibrin • aids in angiogenesis and wound healing These functions result in the use of HA in vocal fold repair, anti-inflammatory materials, drug delivery, void-filling models, cosmetics, and in the food industry. Problems HA is difficult to use as a long-term implant biomaterial because of rapid enzymatic degradation in the body. Solution Conjugating synthetic polymers to HA slows and controls degradation as well as increases its mechanical strength. These materials have been shown to release anti-inflammatory drugs, increase re-
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This note was uploaded on 02/20/2012 for the course BME 201 taught by Professor Schmidt during the Fall '11 term at Purdue.