30391 - Epidemiologic Update: Hepatitis C Miriam J. Alter,...

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Epidemiologic Update: Hepatitis C Miriam J. Alter, Ph.D. Division of Viral Hepatitis Centers for Disease Control and Prevention
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Hepatitis C Virus Infection Clinical entity (non-A, non-B hepatitis) in transfused patients reported late 1960s RNA Flavivirus (Hepacivirus) Discovered using recombinant DNA technology 1989 Bloodborne (primarily) and sexually-transmitted Vaccine difficult to develop Mutations occur during viral replication Substantial heterogeneity (quasispecies) selects for neutralization escape variants
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HCV Accomplishments During Past 15 Years Determined burden of infection and morbidity in the general population Eliminated transfusion-associated infections Characterized the epidemiology Documented >80% decline in incidence Implemented community-based prevention Slowed rates of infection in new IDUs Vaccine developed that may prevent chronic infection (subtype specific) Tissue culture systems effective for growing infectious virus May speed development of new antivirals
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Hepatitis C Virus Infection, United States Hepatitis C Virus Infection, United States New infections per year 1985-89 242,000 2003 30,000 Persons ever infected (1.6%) 4.1 million (3.4-4.9)* Persons with chronic infection 3.1 million (2.5-3.7)* HCV-positives tested 40% Persons with HIV co-infection 225,000 * 95% confidence interval (data from NHANES 1999-2002
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Estimated Incidence of Acute HCV, U.S. 0
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30391 - Epidemiologic Update: Hepatitis C Miriam J. Alter,...

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