Lecture 1 Learning Outcomes

Lecture 1 Learning Outcomes - translation occurs, viral...

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Lecture 1 Learning Outcomes 3-7; 21-23 1. List characteristics of living things, indicate which are seen in viruses and which are not. Organelles, DNA, Cell Wall, genome, evolve Viruses- can’t reproduce by themselves, cant survive outside of host, don’t metabolize, short living 2. Draw the life cycle of a human rhinovirus. HRV is lytic HRV binds to ICAM on Epithelial Cells 3. Give a reason that specific viruses invade only specific cell types. Viruses have a narrow host range- being able to infect cells from a variety of different organs or host species. Specialized to interact with proteins on certain cells Viruses can only invade cells that have those certain cells that the virus interacts with. 4. List three mechanisms by which rhinoviruses evade the immune system. Interacts with specific proteins on the cells surface Endocytosis- RNA realeased into cytoplasm of host cell, replication of genome and
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Unformatted text preview: translation occurs, viral particles formed. Innate immunity -HRV blocks interferon production (interferons stimulate transcription/translation of proteins to attack viruses ex. RNase)-HRV stimulates release of IL-10: Anti-inflammatory, blocks phagocytosis in macrophages Adaptive immunity-Lots of serotypes-antigens-Blocks dendritic cells (immune cells-process antigen material), prevents activation of T cells HRV slows T cells and thereby B cell activation, blocks phagocytosis, increases risk of bacterial infection. 5 cap, 3 poly-A tail ribosomes use initiators to start protein synthesis which recognize the 5 cap viral infection turns off the ability to recognize capped messages, thus viral genome is used Virus has to recognize cell then virus has to get inside the cell Defense Mechanism-HRV...
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This note was uploaded on 02/20/2012 for the course CELL STRUC 301 taught by Professor Tepperman during the Spring '12 term at Ohio State.

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Lecture 1 Learning Outcomes - translation occurs, viral...

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