Biology 311C Lecture 28 - October 31, 2011 Biology 311C...

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October 31, 2011 Biology 311C Lecture 28 DNA is replicated in a semi conservative fashion which means the parent strands split and then the daughter DNA molecules synthesize within. As the origin of replication the two strands of DNA separate and the result is a replication bubble. The bubble grows in both directions, forming two replication forks. Many proteins work together at the replication fork. DNA polymerase builds a new strand of DNA by adding DNA nucleotides one a time. Each new nucleotide must pair up with its complementary nucleotide on the parental strand. A clamp surrounds the RNA and attaches to DNA polymerase, which builds the rest of th new piece as DNA. When the piece is finished, it is released from DNA polymerase. A different DNA polymerase removes DNA and replaces it with DNA, but it cannot finish connecting the pieces. AN enzyme called DNA ligase joins the pieces together DNA polymerase adds nucleotides and it adds it to the 3’ end of the strand. It would not
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This note was uploaded on 02/21/2012 for the course BIO 311 C taught by Professor Mcclelland during the Fall '09 term at University of Texas at Austin.

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