14, 15, DONE!!! circulation

14, 15, DONE!!! circulation - Whats Regulated Type of...

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What’s Regulated Type of regulation What’s wrong Afferent Signal (how/what’s getting sent) Afferent pathway Integrating Center Efferent Pathway (how/wh at’s getting sent) Efferent Signal (what it affects) Changes to (homeostasis) Heart AP Autonomic NS Regulates heart beat, does not initiate AP Autonomous pace-maker activity (SA node) Initiates heart AP Depolarization of plasma membranes Heart Rate (autonomi c NS- changes rate of AP from AS node) Parasympathet ic Resting, want 70 beats/ min Innervati on of heart Vagus nerve innervates SA and AV nodes, releases Ach, Decreases heart rate by muscarinic receptors in myocardial cells binding to Ach, causes few F-type (If) channels opening, increases K permeability (hyperpolarizi ng), longer for
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pacemaker cells to get to threshold Sympathetic stimulation Exercise or trauma, increased demand for O2/nutrients Hormona lly (ephinep hrine, epinephri ne) heart At SA and AV, Increases number of If channels (faster depolarizatio n to threshold), increases T- type Ca (slope of AP steeper) Increases heart rate and stroke volume (below) Stroke volume regulation Sympathetic stimulation Norepine phrine, epineephr ine Contractile cells Intrinsic Mechanism (by heart itself!!!) (Frank- Starling Law) Increased demand on heart When cardiac fibers are stretched from increased venous return, sarcomer es have more cross bridging Heart is stronger when it has more blood in it Increase heart rate and stroke volume, cuases greater venous return Extrinsic Parasympathet
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control ic: regulates heart beat Sympathetic stimulation: increases stroke volume? Innervate AV, SA, contractil e cells, Increase in open CA channels, gives more cross bridget, stronger Epinephri ne from adrenal glands on contractil e cells Increase in open Ca channels, gives more cross bridging, rate of force development and rate of relation increased??? Overall
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This note was uploaded on 02/22/2012 for the course ACCT 1310 taught by Professor Staff during the Fall '10 term at Texas State.

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14, 15, DONE!!! circulation - Whats Regulated Type of...

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