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125 - Nucleic Acids 330 Class Notes 1.25.12 Table of...

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Nucleic Acids 330 Class Notes 1.25.12 Table of Periodic Elements You need carbon, phosphorus, nitrogen, oxygen, hydrogen. Need cofactors like magnesium and salts. What holds individual elements together to form nucleic acids? Slide 3: Insight Leading to the Discovery of DNA Structure Chargaff was interesting in determining the composition of DNA. Found A,T and C, G were in equal. Franklin and Wilkins Found a generic image of structure of DNA, but didn't know how it really looked. Crick and Watson. Modern day structure of DNA. Received Nobel Prize. Slide 4: Schematic of Watson-Crick Structure of DNA Double helical structure. Phosphate backbone holds two helices together Hydrogen bonds between the side groups. Strands are anti-parallel…. Directionality of DNA, strands run in opposite direction. Minor groove and major groove is repeated throughout the helical structure. 1 helical turn of DNA has a defined distance. 3.4 nanometers Slide 5: DNA Can Exist in 3 Different Forms A form is more "compressed" than the B form.
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