130 - 330 Class Notes DNA Replication 1.30.12 Slide 2:...

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330 Class Notes DNA Replication 1.30.12 Slide 2: Mechanism of DNA Replication: The Important Stuff Polymerases require a primer…Serves as a template to get the polymerase started. Bidirectional…Occurs in both directions on the chromosome. Semi-conservative…when you replicate the chromosome, you have one copy of the parental chromosome and one copy of the daugter chromosome. Slide 3: DNA Polymerases Template strand is read in opposity (3' to 5'), but the replication occurs in the 5' to 3' direction. RNA and DNA hybrids through Watson and Crick basepairs. RNA primer will have a free 3' OH group and the polymerase will incorporate base pairs on the end. Primer is in blue in figure and the actual DNA is in black. Slide 4: Overview of DNA Replication Circular chromosome in bacteria. OriC, is where replication begins and ter region is where replication begins. Leading and lagging strand. Slide 5: Table 1.1 DnaA is highly conserved throughout all bacteria. SSB is important in keeping strands that have been melted away from each other so they don't rehybridize. RNase H
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130 - 330 Class Notes DNA Replication 1.30.12 Slide 2:...

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