210 - 330 Class Notes Translation 2.10.12 Slide 2:...

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330 Class Notes Translation 2.10.12 Slide 2: Prokaryotic Transcription Slide 3 Prokaryotes Have Operons Genes with similar functions are usually grouped together within an operon. Usually a single promoter operates the transcription of this operon. Slide 4: Bacterial RNA Polymerase Comprised of four subunits. Two alpha form first as a dimer and then recruit beta and beta prime. Signma comes last. NTD (N-terminal domain) and CTD (C-termianl domain) Core enzyme is the minimal set that is required for activity. Slide 5 Enzyme is flipped on its back in the figure. Omega is believed to be involved in helping to form the core enzyme. Not absolutely required…Polymerase still works fine if you knock out omega gene. Needs sigma to sit down and bind to the DNA. Slide 4: Anatomy of a Promoter Specific sequences on the promoter region that the sigma subunits recognizes. Spacer of 17 bp +1 is the start of transcription. Hexamers.
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210 - 330 Class Notes Translation 2.10.12 Slide 2:...

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