217 - 330 Class Notes Regulation of Gene Expression 2.17.12...

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330 Class Notes Regulation of Gene Expression 2.17.12 Regulation of Transcription Activation Process of turning genes ON or off at different times under various conditions. Reasons for bacteria to regulate genes: Energy conservation Development Products might be toxic Environmental Communication Corrdinate bio processes Food Slide 3: Negative Regulation If you have a repressor bound to an operator sequence, RNAP binding, but repressor prevents RNAP from transcribing through the gene. Slide 4: Positive Regulation Want a strong interaction between operator and repressor to outcompete the RNAP. Slide 5: Positive Versus Negative Regulation by Inducer Positive. Interacts with mRNA to induce translation. Neg. Repressor bound to operator sequence. Ligand binds to repressor. Can be bacterial or environmental. Slide 7: Families of Regulators Protein P4 is acting as a transcriptional activator. Interacts with alpha-CTD and then activates translation. Slide 8: Families of Regulators
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217 - 330 Class Notes Regulation of Gene Expression 2.17.12...

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