30521 - Fraud in Medical Research Emphasis on Statistical Aspects Ted Colton ScD Professor& Chair Emeritus Department of Epidemiology&

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Fraud in Medical Research: Emphasis on Statistical Aspects Ted Colton, ScD Professor & Chair Emeritus Department of Epidemiology & Biostatistics A Continuum with Fuzzy Boundaries Ignorance, Naiveté Carelessness, Sloppiness Improper methods Statistical ‘fallacies’ Fraud Cheating Misconduct Questionable methods Data torturing Data dredging Selective reporting Selective non-reporting Deliberate! Either Unintentional Types of Fraud Plagiarism -not dealt with in this talk Falsification – data alteration Fabrication – made-up data Motivation for Fraud Obtain a desired result, e.g. ‘statistical significance’ Monetary gain, enhancement of prestige Compensate for laziness, sloppiness in data collection Include subjects who would otherwise be excluded Some Historical Instances of Fraud Gregor Mendel Sir Ronald Fisher Sir Ronald Fisher Date : 1865 Place : Bohemia Research : Genetics of garden peas Sir Cyril Burt Date : 1955-66 Place : Great Britain Research : IQs of identical twins reared apart and reared together Leon Kamin Leon Kamin Dr. John Darsee Date : 1981 Place : Harvard Medical School, Peter Bent Brigham Hospital Research : Laboratory and animal studies of cardiovascular disease Data Items in Clinical Trials Prone to Fraud Eligibility criteria Repeated measurements Adverse events Compliance Subject diaries Questions for Consideration...
View Full Document

This note was uploaded on 02/23/2012 for the course STAT 312 taught by Professor Staff during the Fall '11 term at Rutgers.

Page1 / 28

30521 - Fraud in Medical Research Emphasis on Statistical Aspects Ted Colton ScD Professor& Chair Emeritus Department of Epidemiology&

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online