4401 - Hereditary Colorectal Cancer: From Genetic Testing...

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Robert E. Schoen, MD MPH Associate Professor of Medicine and Epidemiology Division of Gastroenterology University of Pittsburgh Hereditary Colorectal Cancer: From Genetic Testing to Prevention
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Colorectal Cancer - Epidemiology 2nd leading cause of CA mortality in U.S. > 130,000 new cases/yr > 48,000 deaths/yr
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Estimated Cancer Deaths in U.S. - 1999 Men Women Lung - 31% Lung - 25% Prostate - 13% Breast - 16% Colorectal - 10% Colorectal - 11%
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Lifetime Risk of CRC (%) All Races 5.88 2.57 Whites 5.99 2.63 Blacks 4.42 2.14 Male + Female LR Dx LR Death SEER, 1992 - 4
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Etiologic Concepts in CRC
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5% 75% 15-20% SPORADIC HNPCC FHx IBD FAP Colorectal Cancer 1%
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Intermediate Endpoint Environment Host Alteration in Large Bowel Epithelium Cancer
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Polymorphisms and CRC Risk Low penetrance susceptibility alleles- Meta Analysis APC I1307K 1.6 (1.2 - 2.1) HRAS1-VNTR 2.5 (1.5 - 4.1) MTHFR ( val/val ) 0.8 (0.6 - 0.9) P53, NAT1, NAT2, GSTM1, GSTT1, GSTP1 exclude >1.7 fold increase Houlston, Gastro 2001;121:282 OR
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This note was uploaded on 02/23/2012 for the course SCI 310 taught by Professor Staff during the Fall '10 term at Rutgers.

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4401 - Hereditary Colorectal Cancer: From Genetic Testing...

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