22561 - Dietary intakes of calcium and vitamin D and risk...

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Unformatted text preview: Dietary intakes of calcium and vitamin D and risk of colorectal cancer in women Jennifer Lin, PhD Division of Preventive Medicine Brigham and Womens Hospital Harvard Medical School, USA jhlin@rics.bwh.harvard.edu 2004 Estimated US Cancer Cases Source: American Cancer Society, 2004. Men 699,560 Women 668,470 32% Breast 12% Lung & bronchus 11% 11% Colon & rectum Colon & rectum 6% Uterine corpus 4% Ovary 4% Non-Hodgkin lymphoma 4% Melanoma of skin 3% Thyroid 2% Pancreas 2% Urinary bladder 20% All Other Sites Prostate 33% Lung & bronchus 13% Colon & rectum Colon & rectum 11% 11% Urinary bladder 6% Melanoma of skin 4% Non-Hodgkin lymphoma 4% Kidney 3% Oral Cavity 3% Leukemia 3% Pancreas 2% All Other Sites 18% 2004 Estimated US Cancer Deaths Source: American Cancer Society, 2004. Men 290,890 Women 272,810 25% Lung & bronchus 15% Breast 10% 10% Colon & rectum Colon & rectum 6% Ovary 6% Pancreas 4% Leukemia 3% Non-Hodgkin lymphoma 3% Uterine corpus 2% Multiple myeloma 2% Brain/ONS 24% All other sites Lung & bronchus 32% Prostate 10% Colon & rectum Colon & rectum 10% 10% Pancreas 5% Leukemia 5% Non-Hodgkin 4% lymphoma Esophagus 4% Liver & intrahepatic 3% bile duct Urinary bladder 3% Kidney 3% All other sites 21% CRC Incidence rate by age & sex Source:National Cancer Institute for 1997-2001 Anatomy of the Colon and Rectum Calcium and vitamin D and colorectal cancer incidence Calcium may reduce risk of colorectal cancer by binding to carcinogenic bile acids and ionized fatty acids. Vitamin D has the potential to regulate cell proliferation and is important in calcium absorption in the gut. The RDA recommends calcium intake of 1000- 1200 mg/day and vitamin D of 5-15 g/day (200- 400 IU/day) for healthy adults. Calcium and colorectal cancer incidence(1) Extensive efforts have been made in epidemiologic studies to evaluate calcium intake and colorectal cancer risk. However, findings have been inconclusive. A meta-analysis of 10 cohort studies observed a 14% risk reduction in the highest quintile of total calcium intake relative to the lowest quintile (Cho et al,2004), while the other metal-analysis study reported no association (Bergsma-Kadijk et al 1996). Calcium and colorectal cancer incidence(2) Clinical trials of calcium supplementation for the prevention of recurrence of colorectal adenomas: (1) one observed a 30% risk reduction after 1 year of follow-up among participants taking 1200 mg/day of calcium (Baron et al, 1999); (2) another trial found that 2000 mg/day of calcium after 3 years of follow-up was associated with a modest risk reduction (Bonithon-Kopp et al, 2000). Vitamin D and colorectal cancer incidence Observational findings on the association between vitamin D intake and colorectal cancer risk have also been inconclusive....
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This note was uploaded on 02/23/2012 for the course SCI 310 taught by Professor Staff during the Fall '10 term at Rutgers.

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22561 - Dietary intakes of calcium and vitamin D and risk...

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