23911 - Infection Tumors Grafts Specificity Memory...

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Unformatted text preview: Infection Tumors Grafts Specificity Memory “Tolerance“ IMMUNITY • “innate resistance“ > 95 % • Ab in eggs • protective memory via Ab (vaccines) • TB: no vaccine • autoimmunity > 30 y, female > male 5 : 1 B cell – Ab responses • local mucosal IgA no T / LN / Peyer • Ag + LPS : IgM (no T H ) • intact virus : IgM (no T H ) • serotypes • monomeric Ag : obligatory T H glycoprotein: LCMV-GP glycoprotein:IND-G rLCMV/INDG rVSV/LCMV-GP reverse genetic glycoprotein exchange between LCMV and VSV LCMV VSV-IND glycoprotein: LCMV-GP glycoprotein:IND-G Only VSVG expressing viruses induce a neutralizing antibody response 3 8 14 20 6 4 2 10 8 12 <1 time after infection (days) 6 4 2 10 8 12 <1 3 8 14 20 time after infection (days) VSV-IND neutralization rLCMV/INDG neutralization 3 8 14 20 time after infection (days) 6 4 2 10 8 12 <1 rVSV/LCMV-GP neutralization 3 8 14 20 time after infection (days) 6 4 2 10 8 12 <1 LCMV-ARM neutralization 2x10 4 PFU rLCMV/INDG i.v....
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This note was uploaded on 02/23/2012 for the course SCI 310 taught by Professor Staff during the Fall '10 term at Rutgers.

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23911 - Infection Tumors Grafts Specificity Memory...

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