30541 - Cancer Prevention Clinical Trials in America Peter...

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Cancer Prevention Clinical Trials in America Peter Greenwald, M.D., Dr. P.H. Division of Cancer Prevention National Cancer Institute
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Lung Cancer Prevention Public Health Approaches cost/tax Smoke-free environment Youth Cessation in adults Anti-nicotine vaccine
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Current/Former Smokers with Bronchial Dysplasia N=112 Anethole Dithiolethione 25 mg TID Results: New lesions No regression of old lesions Lung Cancer Prevention Phase IIb Trial of Anethole Dithiolethione on Bronchial Dysplasia (# sites/grade) Lam et al., 2002 Placebo Repeat Bronchoscopy at 6 months
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BREAST CANCER PREVENTION
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Breast Cancer Prevention Outline Lifestyle Risk Factors Prevention Trials Biomarker End-point/ER Negative Priority
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Lubet,2000 Breast Cancer Prevention Risk Factors for Breast Cancer Weight Gain as an adult/obesity Estrogen & Progestin use Alcohol use
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Breast Cancer Prevention Outline Lifestyle Risk Factors Prevention Trials Biomarker End-point/ER Negative Priority
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13,388 Tamoxifen Placebo Breast Cancer Prevention Breast Cancer Prevention Trial (BCPT) Recruitment
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Breast Cancer Prevention Breast Cancer Prevention Trial (BCPT) E vents Among Participants
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Postmenopausal Women With Osteoporosis (n=7,705) Placebo (n=2,576) Raloxifene 60 mg/d (n=2,557) Raloxifene 120 mg/d (n=2,572) 3-Year Intervention Primary Endpoint: Fractures Secondary Endpoint: Breast Cancer Cummings et al., 1999 Breast Cancer Prevention Multiple Outcomes of Raloxifene Evaluation (MORE) Trial Recruitment
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Placebo Raloxifene Relative Risk (Confidence Interval)
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30541 - Cancer Prevention Clinical Trials in America Peter...

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