36021 - Cancer Prevention Cancer Prevention 預預預預 預預預預 預預 預預預預預 預預預預預預 預預預預預預預 Dr Dos Santos

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Unformatted text preview: Cancer Prevention Cancer Prevention 預預預預 預預預預 預預 : 預預預預預 - 預預預預預預 預預預預預預預 Dr. Dos Santos – Assistant Professor – Loma Linda University School of Public Health What is Cancer What is Cancer 預預預預預 預預預預預 ? ? “ “ A A proliferation of cells proliferation of cells whose unique whose unique trait – loss of normal controls- results in trait – loss of normal controls- results in unregulated growth unregulated growth , lack of , lack of differentiation differentiation , local tissue i , local tissue i nvasion nvasion , and , and metastasis metastasis .” .” The Merck Manual The Merck Manual 預預預預 預預預預 , , 預預預預 預預預預 , , 預預 預預 : : 預預預預預 預預預預預 , , 預預預預 預預預預 , , 預預預預預預預預預 預預預預預預預預預 Treatment Treatment 預預 預預 ? ? Good mostly if cancer is detected at an early stage 預預預預預預預 . Important 重重重 : Early Symptoms/Diagnosis 預預預預預預預 Chemotherapy, Radiotherapy, and Surgery Cell replication Cell replication 預預預預 預預預預 Cell replication Cell replication 預預預預 預預預預 Mutated genes that activate cell growth. For example: RAS gene 25% of cancer cells have RAS gene. Others: C-myc, N-myc - Lung cancer N-myL – Neuroblastoma 預預預預 C-erb-B2 – Breast cancer What activates oncogenes? Smoking Radiation Virus Oncogenes Oncogenes 預預預預 預預預預 Suppressor genes Suppressor genes 預預預預 預預預預 • Normal cells have genes that suppress cell growth. Those genes are affected in cancer cells. • Example: p53 – prevents replication of damaged DNA and promotes cell death in cells with abnormal DNA. Hereditary Influences Hereditary Influences 預預預預預預預預 預預預預預預預預 Some cancers are related to hereditary genetic alterations. Some forms of Leukemia 白白白 Breast Cancer 白白 Colon Cancer 白白白 Regarding the most common diseases, Dr. Lamont Murdoch of Loma Linda University School of Medicine has put it aptly: “faulty genetics loads the gun, . . . lifestyle pulls the trigger.” Environmental factors Environmental factors 預預預預預 預預預預預 Virus Virus 預預 預預 • HPV 白白白白白白白白 – cervical cancer 白白白白 • Cytomegalovirus – Kaposi’s sarcoma (AIDS) 白白白白白 - 白白白白白白白白 • Epstein-Barr - Burkitt’s lymphoma (AIDS) 白白白白白白白白 - Burkitt 白白白 (NPC) • HB virus HB 預預 – liver cancer 白白 • Human retro virus - lymphomas 白白白白白白白 - 白白白 Kaposi Sarcoma - AIDS Kaposi Sarcoma - AIDS 預預預預預預預預 預預預預預預預預 Environmental factors - chemicals Environmental factors - chemicals 預預預預預 預預預預預 -- 預預預預 預預預預 Radiation Radiation 預預 預預 Ultra violet – squamous carcinoma/melanoma skin X Rays – leukemia, lymphomas, melanoma,...
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This note was uploaded on 02/23/2012 for the course SCI 310 taught by Professor Staff during the Fall '10 term at Rutgers.

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36021 - Cancer Prevention Cancer Prevention 預預預預 預預預預 預預 預預預預預 預預預預預預 預預預預預預預 Dr Dos Santos

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