36081 - Research opportunities and challenges in the...

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Unformatted text preview: Research opportunities and challenges in the Dominican Republic Carolina Abuelo MD MSc, HIV Medical Association Clinical Fellow Providence, RI Abnormal Pap smears in Santiago _ Location, location, location! _ Cervical cancer _ HIV _ Pap smears _ Methods _ Ethics Santiago Hospital Regional Universitario Jos Maria Cabral y Bez Cervical cancer _ leading cause of cancer deaths in women in developing countries is cervical CA. _ 83% of cervical CA occur in locations without access to Pap smears _ most common cause of years of life lost in Latin America and the Caribbean _ DR 54% of eligible women screened in 2002 _ 1032 incident cases, about 562 die annually Estimated age standardized incidence rates of cervical CA in Latin America and Caribbean, 2002 Worldwide prevalence of HPV infection is estimated to be between 9% and 13% (all ages) WHO data Estimated prevalence of HPV infection in selected geographic areas (30-45 years old) 13.3% 2 Ontario, Canada 14.5% 3 Morelos State, Mexico 16.6% 4 Concordia, Argentina 15.3% 5 Reims, France 40.2%41.6% 6 Harare, Zimbabwe 18%* ,7 Shanxi Province, China Georgios Papanikolaou _ _ 05/13/1883-02/19/1962 _ presented his results in 1928 in Battle Creek, Michigan _ 1941: test to detect cancer Pap Smear HPV and HIV _ Cervical high risk neoplasia is correlated with HPV _ cervical CA is a criterion for the diagnosis of AIDS as stage C disease _ In a large US multicenter study of the natural history of HIV infection and related diseases to women, cervical cytology was found to be abnormal in 38.3% of HIV+ women. Risk factors for abnormal Pap _ CD4 count, HIV RNA level, detection of HPV, and number of male sex partners within 6 months of enrollment...
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This note was uploaded on 02/23/2012 for the course SCI 310 taught by Professor Staff during the Fall '10 term at Rutgers.

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36081 - Research opportunities and challenges in the...

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